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相关概念视频

REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

143
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
143
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.2K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.2K
Narcolepsy01:07

Narcolepsy

89
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
89
Stages of Sleep01:22

Stages of Sleep

171
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
171
Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

149
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
149
Sleepwalking and Sleep Talking01:17

Sleepwalking and Sleep Talking

119
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
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相关实验视频

Updated: Jun 4, 2025

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
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A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

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在孤立的REM睡眠行为障碍中,纵向网络变化和表转换风险.

Chris C Tang1, Yoshikazu Nakano1, An Vo1,2

  • 1Center for Neurosciences, The Feinstein Institutes for Medical Research, Manhasset, NY, USA.

Nature communications
|December 31, 2024
PubMed
概括

患有REM睡眠行为障碍的人在帕金森病症状出现前几年就会出现渐进的网络变化. 网络进展率可以预测疾病发病,有助于临床试验.

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Noninvasive, High-throughput Determination of Sleep Duration in Rodents
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Noninvasive, High-throughput Determination of Sleep Duration in Rodents

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A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
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科学领域:

  • 神经科学是一个神经科学.
  • 神经学 神经学
  • 医疗成像医学成像

背景情况:

  • 孤立REM睡眠行为障碍 (RBD) 是α-synucleinopathies的一个早期迹象.
  • 了解RBD神经变化的进展对于早期干预至关重要.

研究的目的:

  • 纵向评估RBD患者的代谢网络变化和多巴胺基输入.
  • 为了将基线网络表达与帕金森病或勒维体痴呆症的表现转换与时间相关联.

主要方法:

  • 在一项为期4年的纵向研究中,对13名患有RBD的男性受试者进行了正子发射断层扫描 (PET) 成像.
  • 分析的重点是与帕金森病相关的运动和认知代谢网络以及尾状/状的多巴胺基输入.
  • 一个独立的验证样本被用来将基线网络表达与转换时间相关联.

主要成果:

  • 在4年内,与帕金森病相关的网络表达增加,而多巴胺基输入减少.
  • 随着时间的推移,网络内部和网络之间出现了异常的功能连接,影响了信息流.
  • 基线网络表达与验证样本中代转换的时间相反相关.

结论:

  • 在RBD患者中,网络进展表明临床诊断前几年脑功能受损.
  • 网络进展率是α-synucleinopathies疾病修饰试验的潜在结果指标.