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Updated: Jun 4, 2025

Expression and Purification of Mammalian Bestrophin Ion Channels
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神经递质结合的贝斯特罗芬通道结构揭示了用于疾病治疗的小分子药物向部位

Aaron P Owji1, Jingyun Dong1, Alec Kittredge1

  • 1Department of Ophthalmology, Columbia University, New York, NY, USA.

Nature communications
|December 31, 2024
PubMed
概括

研究人员确定了激活贝斯托芬通道的小分子,如Best1和Best2,为贝斯托芬相关疾病提供了潜在的治疗方法. 4 - 氨基酸 (PABA) 在拯救突变方面表现有前途.

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