尘暴颗粒中的氧化潜力和持久性自由基及其与住院治疗的关联
Linjun Qin1,2,3, Lili Yang4,5, Ling Liu6
1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
沙尘暴 (SDS) 构成健康风险. 在SDS中氧化潜力 (OP) 和持久性自由基 (EPFR) 显著增加了循环和呼吸系统住院,突出了防尘暴策略的必要性.
科学领域:
- 环境健康 环境健康
- 大气化学 大气化学
- 公共卫生 公共卫生
背景情况:
- 沙尘暴 (SDS) 与不利的健康结果有关.
- 氧化潜力 (OP) 和环境持久性自由基 (EPFR) 是SDS诱导的氧化应激的主要贡献者.
研究的目的:
- 在SDS事件期间绘制中国各地OP和EPFR度的地图.
- 量化与SDS相关的OP和EPFR暴露以及因循环和呼吸道疾病住院的相关性.
主要方法:
- 利用来自中国1735个地点 (2021-2023) 的实验数据和随机森林模型来绘制OP和EPFR的地图.
- 在北京SDS活动期间 (2015-2022) 分析了855,869次住院治疗.
- 采用综合暴露-反应模型来评估健康影响.
主要成果:
- EPFRs显示出与循环系统 (3.05%) 和呼吸系统 (2.02%) 疾病住院每10^12旋转/m^3增加的强烈关联.
- OP对循环系统 (3.52%) 和呼吸系统 (2.08%) 疾病住院的每0.2nmol/min/m^3增加显著影响.
- 在SDS期间,OP和EPFR暴露分别占所有原因住院病人的20.47%和27.26%.
结论:
- 与SDS相关的OP和EPFR显著增加了循环和呼吸系统疾病的风险.
- 研究结果为在易受尘埃影响的地区制定有效的风险预防策略提供了关键数据.
- 强调SDS.所造成的大量公共卫生负担.
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