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Updated: Jun 4, 2025

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区域区分的GFAP促进体表达在AAV5转导后的非目标神经元表达中起作用

T Enbar1,2, J W Hickmott2,3, R Siu2,3

  • 1Institute of Medical Sciences, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.

Scientific reports
|December 31, 2024
PubMed
概括

使用腺相关病毒 (AAV) 将星体细胞直接重新编程为神经元,显示了大脑的区域差异. 这项研究研究了运动皮质中的星球细胞转导和基因表达与中间前额叶皮质神经元之间的关系.

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Adeno-associated Virus-mediated Transgene Expression in Genetically Defined Neurons of the Spinal Cord08:41

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相关概念视频

Reporter Genes02:11

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
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