通过食用kombucha调节人类肠道微生物群和健康标志物:一项受控临床研究
Gertrude Ecklu-Mensah1, Rachel Miller2, Maria Gjerstad Maseng3,4,5
1Department of Pediatrics and Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. gecklumensah@health.ucsd.edu.
Scientific reports
|December 31, 2024
概括
在健康的成年人中,康布查的消费显示了肠道微生物组的轻微变化和一些代谢标记物 (如禁食胰岛素) 的变化. 需要进一步的研究来确认发酵食品对健康的益处.
科学领域:
- 微生物学 微生物学
- 人类营养人类营养
- 代谢健康 代谢健康
背景情况:
- 包括kombucha在内的发酵食品因其所感知的健康益处而越来越受欢迎.
- 现有的研究往往缺乏强有力的临床证据,将发酵食品与改善的代谢健康和肠道微生物组调节联系起来.
- 康布查含有益生菌和生物活性化合物,但其对人类健康的影响需要严格调查.
研究的目的:
- 为了研究四周的kombucha补充剂对健康成年人的肠道微生物群和炎症标志物的影响,在西方饮食中.
- 评估生化参数和循环炎症标志物的变化.
- 为了分析对肠道微生物构成的影响,使用中枪元基因组学.
主要方法:
- 一个为期八周的随机对照试验,并进行了为期四周的kombucha干预.
- 参与者 (n=24) 被分为康布查 (n=16) 和对照 (n=8) 组.
- 收集了纵向的便和血液样本,以分析微生物组合和炎症标志物.
主要成果:
- 在整个队列中,没有观察到总体生化参数或炎症标志物的显著变化.
- 康布查小组的禁食胰岛素和HOMA-IR增加,而对照组的HDL胆固醇减少.
- 枪支转基因组学揭示了康布查消费者中韦兹曼尼亚和SCFA产生细菌的丰富性增加.
结论:
- 在健康的成年人中,短期服用康布查补充剂以西方饮食诱导了肠道微生物组合和一些生化参数的适度变化.
- 观察到的效应可能会受到小样本大小和参与者之间的显著变化的影响.
- 需要对更大群体进行进一步的研究,以阐明康布查对健康的具体影响.
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