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Updated: Jun 4, 2025

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工程化tRNAs有效地抑制CDKL5过早终止编解子

Stefano Pezzini1, Aurora Mustaccia2, Pierre Aboa1

  • 1Department of Medical Biotechnology and Translational Medicine, University of Milan, Segrate (Milan), 20054, Italy.

Scientific reports
|December 31, 2024
PubMed
概括

抗编辑的tRNAs (ACE-tRNAs) 为CDKL5缺乏障碍 (CDD) 提供了一个有前途的新策略. 这种方法有效地恢复了具有无意义突变的细胞中CDKL5激酶的全长合成,与以前的药物介导疗法不同.

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