腰椎椎间盘带相关的腰部疼痛患者的多筋肌肉中的微观变化
Shilpa Purushotham1,2, Nathan Hodson3, Carolyn Greig4,5,6
1Centre of Precision Rehabilitation for Spinal Pain (CPR Spine), School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Scientific reports
|December 31, 2024
概括
腰椎间盘 (LDH) 影响多 (MF) 肌肉.
科学领域:
- 整形外科 整形外科 整形外科
- 神经学 神经学
- 肌肉生理学 肌肉生理学
背景情况:
- 腰椎间盘 (LDH) 是腰部疼痛 (LBP) 的常见原因之一.
- 在LDH患者的多筋 (MF) 肌肉中的微观变化仍然不清楚,与之前的研究相矛盾.
- 了解MF的变化对于LBP管理至关重要.
研究的目的:
- 在LDH患者中,将受影响的MF肌肉的显微特征与相邻的ipsilateral和contralateralMF进行比较.
- 调查MF微观变化与临床LBP特征之间的相关性.
- 为了澄清LDH对MF肌肉病理和纤维特征的影响.
主要方法:
- 从30名患有LDH的外科参与者收集了肌肉活检.
- 利用免疫组织化学和光显微镜来分析MF组织.
- 采用了纤维大小和组成的双向ANOVA,病理纤维的单向ANOVA,以及皮尔森对临床关联的相关性.
主要成果:
- 在受影响和不受影响的MF之间,在纤维横截面积,周长或直径上没有发现显著差异.
- 与其他部位相比,在受影响的MF中观察到病理纤维数量显著增加 (p < 0.05).
- I型纤维大小和LBP临床特征之间存在微弱的负相关性;IIA型纤维没有发现相关性.
结论:
- 腰椎间盘主要影响多肌的病态状态,而不是其纤维大小或表型.
- 腰痛临床特征的严重程度与I型肌肉纤维的大小相关.
- 多发性肌肉病理,而不是粗的结构变化,是LDH的关键特征.
相关概念视频
01:29Herniated Intervertebral Disc l: Introduction
Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
01:27Degenerative Disc Disease I: Introduction
Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
01:23Degenerative Disc Disease ll: Pathophysiology
The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...