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Updated: Jun 4, 2025

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揭示和减轻血清素对HRP介导蛋白质标签的抑制作用

Zora Chui-Kuen Chan1, Cheng Qi1, Yuanhong Cai2

  • 1Neurobiology Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.

Scientific reports
|December 31, 2024
PubMed
概括

氨酸出乎意料地抑制了依赖近距离的生物化,这是神经科学的一个关键工具. 一种新型化合物Dz-PEG有效地逆转了这种抑制,提高了蛋白质组学研究的准确性.

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G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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