在晚期癌症中,与免疫检查点阻塞相关的分离反应和治疗结果
Yaping Guan1,2,3, Yu Cui1,2, Yanhong Gong4
1Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, China.
Scientific reports
|December 31, 2024
概括
在接受免疫检查点抑制剂治疗的癌症患者中,与免疫相关的分离反应 (DR) 是不常见的,但与比真正的进展性疾病更好的预后有关. 局部治疗可能会改善DR患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 免疫相关分离反应 (DR) 是接受免疫检查点抑制剂 (ICI) 的癌症患者中新发现的一种现象.
- 了解DR的频率,结果和预测因素对于优化癌症治疗策略至关重要.
研究的目的:
- 评估使用PD-1/PD-L1抑制剂治疗的癌症患者中DR的发生率,治疗结果和预测因素.
- 将DR患者的预后与真正进展性疾病 (PD) 和无反应患者的预后进行比较.
主要方法:
- 从接受ICI单疗法或组合治疗的泛瘤队列 (n=177) 的临床病理数据的回顾性分析.
- 在接受免疫治疗的高级非小细胞肺癌 (NSCLC) 患者的独立队列中进行验证.
- 无进展生存率 (PFS) 和总生存率 (OS) 是主要的结果指标.
主要成果:
- 在泛瘤队列中的6.8%,在NSCLC队列中的12.5%观察到DR.
- 与真正进展性疾病 (PD) 患者相比,DR患者的PFS和OS中位数显著更长.
- 在DR患者的局部治疗与改善的OS (32.3个月与21.9个月) 相关.
结论:
- 与真正PD患者相比,经历DR的癌症患者表现出相对有利的预后.
- 继续ICI治疗和局部治疗生长的病变可能会提高选择DR患者的生存率.
- 没有特定的临床特征被确定为DR的显著预测因素.
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