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基于异常的抵抗运动对整个月经周期和口服避孕药周期的骨 (重建) 标记物的影响
Isabel Guisado-Cuadrado1, Nuria Romero-Parra2,3, Rocío Cupeiro2
1LFE Research Group, Department of Health and Human Performance. Faculty of Physical Activity and Sport Sciences, Universidad Politécnica de Madrid, Calle de Martín Fierro, 7, 28040, Madrid, Spain. i.guisadoc@upm.es.
European journal of applied physiology
|December 31, 2024
概括
在绝经前的女性中,古怪的运动急剧降低了骨质再吸收标志物β-CTX-1,特别是在中期的白色阶段. 口服避孕药使用者显示较低的骨形成标志物P1NP,突出显示了激素对骨代谢的影响.
科学领域:
- 运动生理学 运动生理学
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 月经周期阶段和口服避孕药的使用显著影响女性性激素.
- 性激素在调节骨循环方面发挥着至关重要的作用.
- 了解运动对不同荷尔蒙状态的骨标记物的影响,对女性健康至关重要.
研究的目的:
- 检查异常阻力运动对骨周转标记 (P1NP和β-CTX-1) 的急性影响.
- 研究性激素在月经周期的波动和口服避孕药的使用对这些标记物的影响.
主要方法:
- 九名阴女性和十名口服避孕药 (OC) 用户接受了古怪的抵抗运动 (10x10次,4s古怪阶段).
- 运动在特定阶段进行:月经周期 (MC) 用户的早期卵泡 (EFP),晚期卵泡 (LFP) 和中期卵泡 (MLP).
- 在戒断 (WP) 和活跃服用药物 (APP) 阶段,OC使用者进行了运动.
主要成果:
- 17β-雌醇水平在MC和OC阶段有显著的变化.
- 孕激素在MLP阶段是最高的.
- 在阴女性中,与LFP相比,MLP中的β-CTX-1较低 (p=0.044).
- 在大多数阶段 (p<0.05) 中,肌女性的P1NP水平比OC使用者高 (p<0.05).
- 所有参与者的β-CTX-1度在运动后2小时比运动前更低 (p<0.001).
结论:
- 骨再吸收标志物β-CTX-1在月经周期中期较低,强调需要将测量标准化到特定的月经周期阶段.
- 口服避孕药使用者显示P1NP水平降低,这表明需要进一步研究合成与内源激素对骨健康的长期影响.
- 急性异常运动有效地降低了骨周转标志物,观察到相位依赖的变化.
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