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Updated: Jul 8, 2026

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微囊素-LR暴露通过通过MAPK4/GATA2/SNCA和PP2A/GRK路径诱导α-Syn聚合来损害神经元

Minghao Yan1,2, Huifang Wu1,2, Tong Wu1,2

  • 1State Key Laboratory of Analytical Chemistry for Life Science, Division of Anatomy and Histo-Embryology, Medical School, Nanjing University, Nanjing, 210093, Jiangsu, China.

Molecular neurobiology
|December 31, 2024
PubMed
概括

微囊素-LR (MC-LR) 是一种神经毒素,促进了帕金森氏症.

关键词:
在GATA2/MAPK4/SNCA路径中.微囊素LR-LR的使用情况神经元的亡是神经元的亡.在PP2A/GRKs路径上.α-Synuclein 是一种蛋白质.

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MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...