吸入气治疗可能没有足够的效果来缓解REBOA诱导的氧化应激
Yosuke Matsumura1,2, Yosuke Hayashi3, Makoto Aoki4
1Department of Intensive Care, Chiba Emergency and Psychiatric Medical Center, 6-1 Toyosuna, Mihama-ku, Chiba City, Chiba, 261-0024, Japan. yousuke.jpn4035@gmail.com.
Scientific reports
|December 31, 2024
概括
吸入气并没有显著改善猪模型中出血性休克和大动脉闭塞的结果. 该疗法在复苏性内血管气球关闭主动脉 (REBOA) 后的生存,乳酸水平或肠道损伤中没有显著差异.
科学领域:
- 医学研究 医学研究
- 创伤外科 手术 创伤外科
- 生物医学工程 生物医学工程
背景情况:
- 出血性休克是创伤死亡的主要原因.
- 复苏性血管内气球阻塞大动脉 (REBOA) 用于严重的出血休克,但可能导致氧化应激损伤.
- 气治疗正在被探索其潜在的抗氧化特性.
研究的目的:
- 在猪模型中调查吸入气对减轻REBOA后缺血-再输液损伤 (IRI) 的疗效.
- 评估气对生存,乳酸盐水平,氧化应激生物标志物和肠道损伤的影响.
主要方法:
- 十只健康的母猪接受了诱导的40%的出血休克,随后进行了60分钟的1区REBOA.
- 组在REBOA通胀期间吸入了2%的气.
- 评估的结果包括生存时间,乳酸盐,8-基-2'-脱氧氨酸 (8-OHdG) 和乳房病理.
主要成果:
- 在对照组和组之间没有观察到生存率的显著差异 (4/5对5/5).
- 乳酸盐度和8-OHdG度在基组中呈现较低度的趋势,但在统计学上并不显著.
- 皮质粘膜损伤在两组之间病理学等级没有显著差异.
结论:
- 在这种猪模型中,气吸入疗法在缓解REBOA诱导的缺血-再输液损伤方面没有显著的益处.
- 虽然死亡率和生物标志物的轻微减少被建议,但需要进一步的证据来支持疗在这种情况下的疗效.
更多相关视频
相关概念视频
Respiratory Assessment: Purpose and Indications
1.0K
Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
1.0K
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
171
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
171
Acute Respiratory Failure-V
123
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
123
Physiological Control of Respiration
1.9K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
1.9K
Peroxisomes
10.5K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
10.5K
Oxygen Transport in the Blood
2.4K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
2.4K


