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银病治疗在动脉样硬化的稳定:一个系统的审查
Lixin Ji1, Sowmya Ravi2, Laura Wright3
1Department of Dermatology, Tulane School of Medicine, 131 S. Robertson Street, 11th Floor, New Orleans, LA, 70112, USA. lji2@tulane.edu.
Archives of dermatological research
|December 31, 2024
概括
瘤坏死因子-α (TNF-α) 抑制剂通过改善血管健康标志物,显著降低了牛皮患者的动脉样硬化进展. 干白素-17 (IL-17) 抑制剂也显示出有效性,特别是在减少非化斑块负担方面.
科学领域:
- 皮肤病学和心血管医学
背景情况:
- 牛皮与增加动脉样硬化风险有关.
- 在牛皮中最小的疾病活性可能会影响心血管结果.
研究的目的:
- 系统地审查牛皮治疗对动脉样硬化进展的影响.
- 为了比较各种疗法的疗效,包括生物药物,在动脉样硬化标志物上.
主要方法:
- 在PubMed,Embase和Web of Science (2000-2023) 的系统文献搜索.
- 包括21项研究来量化成人牛皮患者的动脉样硬化标志物 (例如,CIMT,CCTA,aPWV,FAI).
- 治疗的分类包括TNF-α抑制剂,IL-17抑制剂,DMARDs和光疗.
主要成果:
- 与没有治疗,光疗和IL-12/23抑制剂相比,TNF-α抑制剂显著改善了动脉样硬化标志物 (CIMT,aPWV,FAI,CRP).
- IL-17 抑制剂与TNF-α 抑制剂具有可比的FAI 降低,并且在非化斑块负担中具有更高的降低.
- 酸改善了胆固醇代谢,TNF-α抑制剂增强了内皮功能.
结论:
- TNF-α抑制剂在减轻牛皮患者动脉样硬化进展方面非常有效.
- IL-17抑制剂提供了一种有价值的替代品,特别是在减少非化斑块负担方面.
- 将TNF-α和IL-17抑制剂整合到治疗方案中可以改善患有并发性动脉样硬化症的牛皮患者的心血管结果.
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