基于价值的指标特定定价和加权平均定价:癌症药物的估计价格和成本节省
Daniel Tobias Michaeli1,2, Thomas Michaeli3,4,5,6
1Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. danielmichaeli@yahoo.com.
PharmacoEconomics
|December 31, 2024
概括
基于价值的癌症药物定价可以节省数十亿美元. 标志性定价可能会增加罕见疾病的成本,而加权平均定价提供更广泛的节省,并降低超罕见疾病的成本.
科学领域:
- 卫生经济学 卫生经济学
- 制药政策 制药政策
- 在瘤学瘤学.
背景情况:
- 美国医疗保险和医疗补助系统目前的药品定价没有考虑补充适用药的价值.
- 对于具有多种用途的药物,已经提出了基于价值的定价模型,包括指示特定和加权平均方法.
研究的目的:
- 根据基于价值的适用性和加权平均定价模型,估计癌症药物的潜在降价和成本节约.
- 分析这些定价策略对整体医疗保健支出的影响.
主要方法:
- 从多个来源收集了FDA批准的癌症药物和适用情况 (2003-2020) 的数据.
- 多变量回归分析预测了附加指示的基于价值的指示特定价格.
- 使用特定指标的价格和流行数据来估计加权平均价格和成本节省.
主要成果:
- 在2020年,医疗保险和医疗补助计划花费了282亿美元,用于123种癌症药物,有308种适应症.
- 基于价值的标志性定价可以节省30亿美元 (10.6%) 的成本,但会增加超罕见疾病的价格.
- 基于价值的加权平均定价可以将价格降低4.6%,节省30亿美元 (10.6%),还可以降低超罕见疾病的成本.
结论:
- 实施以价值为基础的,适用于特定的和加权平均价格的定价可以更好地使药物价格与不同适用于不同适用于药物的价值保持一致.
- 这些定价策略提供了一种机制,以减少多种批准使用的癌症药物的总体支出.
更多相关视频
10:13Non-Destructive Evaluation of Regional Cell Density Within Tumor Aggregates Following Drug Treatment
Published on: June 21, 2022
2.1K
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
10.9K
相关概念视频
01:21Cancer Survival Analysis
328
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328
02:50Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
120
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
120
01:30Cancer Vaccines
338
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
338
01:20Actuarial Approach
61
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
61