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大脑18FDG-PET模式在认知障碍的老年患者中,患有双相情感障碍

Nouredine Saleh¹, Capucine Blaise², Amina Daoudi²

¹Department of nuclear medicine, Centre de Neurologie Cognitive, GHU AP-HP.Nord, Site Lariboisière Fernand-Widal, 200 rue du Faubourg Saint-Denis, Paris, 75010, France.

International journal of bipolar disorders

|December 31, 2024

概括

患有双相情感障碍 (BD) 的认知障碍的老年患者没有显示出大脑葡萄糖代谢异常,这表明他们的认知衰退可能不是来自常见的神经退行性途径. 需要进一步的研究来理解这些过程.

科学领域:

神经科学是一个神经科学.
老年病的医生老年病的医生
核医学就是核医学.

背景情况:

患有双相情感障碍 (BD) 的老年患者面临痴呆症的风险增加.
在BD中驱动痴呆症的机制尚未完全理解.
FDG-PET成像可以检测降低的葡萄糖代谢,表明神经退行.

研究的目的:

在患有双相情感障碍 (BD) 和认知障碍的老年患者中调查大脑葡萄糖代谢.
使用FDG-PET成像来探索BD认知衰退的潜在潜在机制.
提高BD患者认知障碍的诊断准确度.

主要方法:

对32名认知障碍老年BD患者的FDG-PET扫描进行了回顾性分析.
与35个非退行性对照 (NDC) 和患有阿尔茨海默病 (AD),前性痴呆症 (FTD) 和患有莱维体痴呆症 (DLB) 的患者组进行了比较.
使用SPM软件进行Voxel-wise统计分析,对年龄和性别进行控制.

主要成果:

与NDC相比,在BD患者中没有检测到显著的皮质低代谢.
在AD,FTD和DLB组中观察到明显的低代谢模式.
在BD中晚期认知障碍似乎不是由单个常见的神经退行过程引起的.

结论:

在认知障碍的老年BD患者中缺乏异常的皮质新陈代谢表明,非神经退行性机制可能是他们认知障碍的基础.
通过使用多种生物标志物的进一步调查对于了解BD认知衰退中涉及的大脑过程至关重要.
更好的理解可能会导致更好的管理策略的认知障碍在BD.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.双极性障碍是一种双极性障碍.痴呆症是一种痴呆症.年长的老人.神经退行性疾病是一种神经退行性疾病.

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