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在AJCC分期系统中表征ypT0N1胃腺癌患者

Albert Leng¹, Vrinda Madan², Manuj Shah¹

¹Division of Gastrointestinal Surgical Oncology, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Annals of surgical oncology

|December 31, 2024

概括

患有ypT0N1分期的胃癌患者的生存结果明显较差. 这种ypT0N1阶段与AJCCIIB和III阶段的疾病更接近,影响了治疗和预后.

科学领域:

在瘤学瘤学.
胃肠病学胃肠病学
癌症的分期癌症的分期

背景情况:

在美国,标准的胃癌治疗包括术后化疗.
不一致的ypTNM分期,如ypT0N1,在治疗后偶尔会发生.
准确的ypT0N1分类对于预后和治疗计划至关重要.

研究的目的:

用ypT0N1分期来描述胃癌患者的存活率.
将ypT0N1患者的生存结果与其他ypTNM阶段进行比较.
在AJCC分阶段系统中为ypT0N1的分类提供信息.

主要方法:

利用国家癌症数据库 (NCDB) 对接受新辅助化疗的胃腺癌患者 (2004-2021) 的数据.
将患者分层分为ypT0N0,ypT+N0,ypT+N1和ypT0N1组.
采用多变量Cox比例危险回归来分析5年和10年生存率.

主要成果:

分析了28,985名患者;1.1%的人有ypT0N1分期.
与ypT0N1患者相比,ypT0N1患者面临105%更高的5年死亡风险 (aHR2.05) 和86%更高的10年风险 (aHR1.86) 与ypT0N0.0相比.
ypT0N1结果比节点负 (ypT0N0) 疾病更糟糕.

结论:

患有ypT0N1胃癌的患者的生存率低于节点负的同行.
ypT0N1疾病的生存模式与AJCCIIB和III阶段的生存模式相似.
这一发现需要仔细考虑分期和治疗策略.

关键词:

胃腺癌是胃腺癌.新辅助疗法是一种新辅助疗法.幸存的生存方式

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