诊断延迟,年龄较大,以及诊断时的荷尔蒙水平,都会影响壮症患者的疾病负担和死亡率
Valentina Gasco1, Nunzia Prencipe2, Daniela Cuboni2
1Division of Endocrinology, Diabetes, and Metabolism, Department of Medical Science, University of Turin, Turin, Italy. valentina.gasco@unito.it.
Journal of endocrinological investigation
|December 31, 2024
概括
诊断时的年龄较大显著影响了壮症并发症,而诊断延迟影响了荷尔蒙水平和死亡率. 早期诊断对于管理这种罕见疾病至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 罕见疾病 罕见疾病
- 心血管健康 心血管健康
背景情况:
- 巨症的特征是生长激素过多,往往会出现诊断延迟,特别是在老年人中.
- 延迟诊断和晚年与壮病患者的死亡率增加和系统性并发症有关.
- 年龄,诊断延迟,荷尔蒙水平和疾病结果之间的确切关系需要进一步阐明.
研究的目的:
- 调查诊断时的年龄和诊断延迟对荷尔蒙特征,心脏代谢并发症和壮症死亡率的影响.
- 为了澄清年龄,诊断延迟和壮症疾病负担之间的相互作用.
主要方法:
- 对203名壮病患者的回顾性分析.
- 患者根据诊断时的年龄 (<65岁和≥65岁) 和诊断延迟 (≤5岁和≥5岁) 分层.
- 评估了临床和荷尔蒙数据,心脏代谢并发症和死亡率.
主要成果:
- 诊断时的年龄较大与心脏代谢并发症有很强的相关性,而诊断延迟的影响较小.
- 年轻的年龄和更长的诊断延迟与更高的生长激素 (GH) 水平有关.
- 年龄较大,IGF-I水平较高和男性性别预测激素疾病负担增加和心脏代谢并发症.
- 在老年患者和诊断延迟时间长的患者中观察到死亡率增加.
结论:
- 诊断时的年龄较大是壮病中心脏代谢并发症的主要驱动因素.
- 诊断延迟和年龄较大是壮病死亡率的重要预测因素.
- 了解这些因素对于优化管理策略和改善壮病患者的治疗结果至关重要.
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