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人类乳头瘤病毒感染和鼻逆转乳头瘤复发:一个元分析

Fayssal Alqudrah¹, Sharwani Kota¹, Jason Morgan¹

¹Department of Otolaryngology-Head and Neck Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

|December 31, 2024

概括

人类乳头瘤病毒 (HPV) 感染可能会增加鼻逆转乳头瘤 (SNIP) 复发的风险. 这种关联似乎独立于HPV亚型,尽管由于研究变异性,需要进一步研究.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
在瘤学瘤学.
病毒学病毒学

背景情况:

鼻反向乳头瘤 (SNIP) 是一种良性瘤,具有显著的复发率.
人类乳头瘤病毒 (HPV) 感染在SNIP复发中的作用仍然存在争议.
之前的研究就HPV和SNIP复发之间的关联产生了相互矛盾的结果.

研究的目的:

系统地审查和分析现有文献,以澄清HPV感染和SNIP复发之间的关联.
为了确定在HPV阳性与HPV阴性SNIP中复发的合并几率比率 (OR).
调查HPV亚型 (低风险与高风险) 是否影响SNIP复发风险.

主要方法:

在PubMed,Embase和Scopus数据库中进行了系统的搜索.
包括病例控制研究报告SNIP复发和由PCR和ISH确定的HPV状态.
进行了元分析,以计算聚合的OR和95%置信区间 (CI).

主要成果:

分析了25项研究,其中包括1116种良性SNIP瘤.
与HPV阴性瘤相比,HPV阳性SNIP的复发组合OR为2.05 (95% CI:1.31-3.19).与HPV阴性瘤相比,复发的组合OR为2.05.
与HPV相关的复发风险增加在低风险和高风险HPV亚型之间没有统计学意义.

结论:

感染HPV与SNIP复发的风险增加有关.
这种增加的风险似乎独立于HPV亚型.
最近研究中的变异性需要进一步调查HPV-SNIP复发关系.

关键词:

人类乳头瘤病毒人类乳头瘤病毒逆向乳头瘤的发生这是一个元分析.复发性复发性复发性鼻瘤是一种鼻瘤.

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