对感染登革热患者肝功能测试的分析
S Khanduker1, M Mojumder, R Ahmed
1Dr Sadia Khanduker, Associate Professor, Department of Biochemistry, Bangladesh Medical College, Dhaka, Bangladesh;
Mymensingh medical journal : MMJ
|December 31, 2024
概括
登革热病毒感染通常会导致肝功能障碍,大多数患者表现出AST和ALT等肝酶的升高. 较高的酶水平和较低的白蛋白水平表明预后较差,特别是在严重的登革热病例中.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 登革热是一个重要的全球公共卫生问题.
- 登革热病毒感染具有不同的临床表现.
- 肝功能障碍是登革热患者经常观察到的并发症.
研究的目的:
- 评估登革热感染个体中肝功能障碍的患病率和程度.
- 评估登革热病毒对肝功能测试 (LFT) 的影响.
- 为了将LFT异常与登革热的严重程度和患者的结果相关联.
主要方法:
- 观察性,横截面研究设计.
- 从120例血清学确认的登革热病例中分析了生物化学肝功能测试.
- 将患者分为登革热 (DF),登革热出血热 (DHF) 和登革热休克综合征 (DSS) 的分类.
主要成果:
- 在73.0%和88.0%的患者中,分别观察到高氨基转移酶 (ALT) 和酸氨基转移酶 (AST).
- 在患有出血和未幸存者的患者中,ALT,AST和总胆红素的显著升高.
- 较低的血清白蛋白水平与登革热冲击综合征 (DSS) 有关.
结论:
- 肝功能障碍在所有登革热感染类型中都是常见的.
- AST升高可能是登革热感染的早期指标.
- 在登革热管理中,ALT,胆红素和白蛋白的异常可能是不良的预后标志物.
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