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Updated: Jun 4, 2025

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
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Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

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一个可扩展的诱导性淘汰系统,用于研究疟疾寄生虫的基本基因功能.

Abhinay Ramaprasad1, Michael J Blackman1,2

  • 1Malaria Biochemistry Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK.

Nucleic acids research
|December 31, 2024
PubMed
概括

研究人员开发了SHIFTiKO,这是针对疟疾寄生虫的可扩展基因编辑工具. 这种系统可以对重要基因进行大规模研究,有助于了解寄生虫的传播和识别新的药物点.

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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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