共享的遗传因素和与新鲜水果摄入的相互作用有助于四种类型的状细胞癌
Mengqing Mo1,2, Can Hou3, Huangbo Yuan4
1Department of Epidemiology & Ministry of Education Key Laboratory of Public Health Safety, School of Public Health, Fudan University, Shanghai, China.
PloS one
|December 31, 2024
概括
这项研究揭示了泛状细胞癌 (Pan-SCCs) 的共同遗传和环境风险因素. 发现了新的遗传变异和人类白细胞抗原 (HLA) 关联,为SCC研究提供了新的目标.
科学领域:
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 单状细胞癌 (Single-SCCs) 的风险因素已知,但泛状细胞癌 (Pan-SCCs) 的共同遗传和环境因素仍然不清楚.
- 了解这些共同因素对于制定各种SCC的有效预防和治疗策略至关重要.
研究的目的:
- 通过使用多omics方法来识别泛SCCs的共同生殖基因和环境风险因素.
- 描述人类白细胞抗原 (HLA) 变异在SCC易感性中的作用.
- 发现泛SCCs的新型遗传位置和潜在生物标志物.
主要方法:
- 基于英国生物库数据的全基因组关联分析 (GWAS) (1,928个泛SCC病例,7,712个对照).
- 计算高分辨率的HLA等位基因和氨基酸序列.
- 整合转录组和蛋白质数据库进行多omics分析,包括生物信息学和途径丰富分析.
主要成果:
- 确定了与SCC进展相关的六种新型索引单核酸多态 (SNP),显示与新鲜水果摄入的相互作用.
- 特定的HLA等位基因 (HLA-A*01) 和氨基酸位置与SCCs独立相关.
- 差异表达基因 (DEGs) 在干细胞调节方面得到了丰富,而氨酸 (KRT) 基因成为潜在的SCC标记物.
结论:
- 这项研究阐明了SCC易感性的分子基础,突出了共同的遗传共同点和新的风险位置.
- 已识别的HLA变体和基因标为SCCs的病原体提供了洞察力,并为未来的功能研究和治疗开发提供了潜在途径.
相关概念视频
Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
Skin Cancer
2.9K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
2.9K
Cancers Originate from Somatic Mutations in a Single Cell
11.3K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
11.3K
Mutagenicity and Carcinogenicity
1.1K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.1K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.2K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.2K
Loss of Tumor Suppressor Gene Functions
4.6K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.6K


