由于同时感染卡波西肉瘤相关疹病毒和SARS-CoV-2而导致细胞基因表达的改变:对疾病严重性的影响
Jungang Chen1, Jiaojiao Fan1, Priyangi A Malaviarachchi2
1Department of Pathology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Journal of medical virology
|December 31, 2024
概括
严重的COVID-19 (冠状病毒疾病2019) 可以重新激活卡波西的肉瘤相关性疹病毒 (KSHV). 这项研究表明,SARS-CoV-2 (导致COVID-19的病毒) 感染会诱导KSHV的重新激活,可能会增加患者的癌症风险.
科学领域:
- 病毒学 病毒学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 由SARS-CoV-2引起的COVID-19大流行病导致全球数百万人死亡.
- 伴随性疾病,包括癌症和其他感染,加剧了COVID-19的结果.
- 临床观察表明,在严重的COVID-19患者中,像KSHV这样的人类疹病毒的重新激活.
研究的目的:
- 调查SARS-CoV-2感染对先前存在的KSHV感染的影响.
- 为共同感染研究建立细胞模型.
- 探索SARS-CoV-2感染期间KSHV重新激活的基础分子机制.
主要方法:
- 使用A549-hACE2细胞建立了共感染系统.
- 被活体SARS-CoV-2和KSHV感染的细胞.
- 进行了转录组分析,以评估基因表达变化.
主要成果:
- 活体SARS-CoV-2感染显著诱导了共感染细胞中的KSHV溶性活性化.
- 转录组分析揭示了细胞基因表达模式的实质性变化.
- 在KSHV感染的细胞中观察到基因表达的变化,有或没有SARS-CoV-2联合感染.
结论:
- 感染SARS-CoV-2可以触发KSHV的重新激活.
- 这种重新激活可能会增加之前有KSHV感染的个体患重症COVID-19的风险.
- 研究结果表明,COVID-19,KSHV的重新激活和与病毒相关的癌症风险增加之间存在潜在联系.
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