化基,基和基甲基糖化物来自红树林内生菌 Fuscoporia sp. A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A6 A2A7 A2A6 A2A6A7 A2A7 A2A8 A1 A1 A1 A1 A1 A1 A1 A1 A1 A1 A1 A1 A1 A1 A1 A1 A1 A1 A2 A1 A1 A1 A1 A1 A2 A1 A1 A1 A2 A1 A1 A1 A2 A1 A1 A1 A2 A1 A1 A2 A1 A1 A1 A2 A1 A1 A1 A2 A1 A1 A2 A1 A1 A1 A2 A1 A1 A2 A1 A1 A2 A1 A1 A1 A1 A2 B1 A1 A1 A1 A2 B1 A1 A1 A1 A2 B1 A2 B1 A1 B2 B2 B2 B2 B2 B3 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1

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Isolation and Screening from Soil Biodiversity for Fungi Involved in the Degradation of Recalcitrant Materials

Isolation and Screening from Soil Biodiversity for Fungi Involved in the Degradation of Recalcitrant Materials

Published on: May 16, 2022

Yue Gao¹, Jing-Ling Ren¹, Zi-Cen Fang¹

¹School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.

Chemistry & biodiversity

|December 31, 2024

概括

从一个红树林真菌中分离出了12种新的葡萄糖类,包括化化合物. 富斯科酸C显示神经保护,而富斯科酸G显示抗炎活性.

科学领域:

自然产品化学自然产品化学
菌类学菌类学是指菌类学.
药理学药理学是指药理学的学科.

背景情况:

红树林内生菌是新型生物活性化合物的丰富来源.
福斯科波利亚 sp. A2A6是一种以前未经描述的来自红树林环境的真菌.

研究的目的:

从Fuscoporia sp.中分离和描述新的化合物. A2A6.6. A2A6.6. A2A6.6. A2A6.6. A2A6.6. A2A6.6. A2A6.6. A2A6.
评估分离化合物的生物活性,重点关注神经保护和抗炎作用.

主要方法:

使用色谱技术分离和净化化合物.
使用高分辨率电喷射电离质谱法 (HRESIMS),核磁共振 (NMR) 光谱法和单晶X射线衍射的结构阐明.
生物分析包括神经元细胞中氧化损伤的评估和微质细胞中循环氧化酶-2 (COX2) 表达的评估.

主要成果:

鉴定出了12种新的葡萄糖体,即A-L (1-12) 基体,包括类,类和类.
隔离的10种化合物是单或二的.
富斯科波C (3) 在HT-22细胞中表现出剂量依赖的神经保护作用,防止过氧化诱导的氧化应激.
富斯科G (7) 通过降低用脂聚糖激发的BV2细胞中的COX2表达来表现出抗炎活性.

结论:

这项研究成功地分离和鉴定了来自红树林内菌的12种新型葡萄糖类.
富斯科酸C和G分别具有显著的神经保护性和抗炎性质,突出显示了它们的治疗潜力.

关键词:

福斯科波里亚 sp.它具有抗炎活性,具有抗炎活性.化化类葡萄糖化物.化烯基葡萄糖化物化烯基葡萄糖化物化甲酸乙类葡萄糖化物红树林内性真菌红树林内性真菌神经保护作用的神经保护作用.

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