比其部分的总和还要多:多发性硬化症中多重脑网络的核心外周受损
Giuseppe Pontillo1,2,3, Ferran Prados1,4,5, Alle Meije Wink2
1Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, UK.
Human brain mapping
|December 31, 2024
概括
多模式脑MRI分析显示,多发性硬化症 (PwMS) 患者的网络组织中断. 这种核心-外围结构的破坏是 PwMS 疾病严重程度和认知障碍的潜在生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 在Connectomics上,我们提供了连接.
- 系统神经科学 系统神经科学
背景情况:
- 在使用各种MRI技术的多发性硬化症 (PwMS) 患者中观察到大脑网络中断,但结果在连接领域各不相同.
- 现有研究通常独立分析结构,扩散或功能MRI数据,可能缺少集成网络的改变.
研究的目的:
- 开发和应用一个多层网络方法,整合结构MRI (sMRI),扩散MRI (dMRI) 和功能MRI (fMRI),以更好地描述大脑组织.
- 在PwMS中使用这种多式模式方法来调查大脑核心-外围组织的变化.
- 探索这些网络改变与临床结果的关联,包括残疾和认知功能.
主要方法:
- 一项回顾性横截面研究,利用PwMS的多式脑MRI数据和MAGNIMS网络中的健康对照.
- 将sMRI,dMRI和静止状态fMRI数据集成到一个多层网络框架中,以计算区域正确性和正确性破坏指数 (κ).
- 使用线性模型和随机森林分析来评估 κ 与疾病状况,身体残疾 (EDSS) 和认知障碍 (SDMT) 的关联.
主要成果:
- 普华永道展示了多重核心-外围组织 (κ) 的显著破坏,表明与控制相比,全球核心-外围结构减弱.
- 干扰干扰指数 (κ) 与临床表型,身体残疾 (EDSS) 和认知障碍 (SDMT) 有显著的相关性.
- 多重体 κ 成为疾病状况和认知障碍的关键预测指标,优于传统的MRI测量和单层网络分析.
结论:
- 多层网络分析为整合多模式MRI数据提供了全面的框架,揭示了对大脑组织的生物学和临床有意义的见解.
- 多重核心-外围结构的破坏是PwMS中疾病严重程度和认知障碍的强有力的指标.
- 这种连接的方法有望成为评估疾病进展和指导多发性硬化症治疗策略的潜在成像生物标志物.
更多相关视频
08:23A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
11.0K
09:52Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
Published on: February 23, 2020
9.0K
相关概念视频
01:13Functional Brain Systems: Reticular Formation
1.3K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
1.3K
01:14Brain Imaging
193
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
193
01:30Organization of the Brain
625
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
625