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Updated: Jun 4, 2025

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治疗老年患者严重抑郁症多重非侵入性脑刺激的比较疗效:基于随机对照试验的系统审查和网络元分析研究

Yang Yang¹, Jianglin Chen¹, Min Yu¹

¹Department of Neurology, Affiliated Hospital of North Sichuan Medical College; Institute of Neurological Diseases, North Sichuan Medical College, Nanchong 637000, Sichuan, China.

Psychiatry research

|December 31, 2024

概括

重复性跨磁刺激 (rTMS) 和甲爆刺激 (TBS) 显示出对老年人治疗严重抑郁症 (MDD) 的前景. 这些非侵入性脑刺激 (NIBS) 技术似乎有效,并可能改善认知功能.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
老年学是一门学科.

背景情况:

大型抑郁症 (MDD) 显著影响老年人,往往导致认知能力下降和生活质量下降.
非侵入性脑刺激 (NIBS) 技术正在成为MDD的潜在治疗方法.
在老年人群中,NIBS的比较疗效和安全性需要进一步研究.

研究的目的:

为了比较各种NIBS技术在老年患者中治疗MDD的疗效和认知效应.
为这个人口群体确定最有效的NIBS干预措施.

主要方法:

在PubMed,EMBASE,Cochrane图书馆和Web of Science数据库中进行了系统的文献搜索,直到2024年3月.
这项分析包括17项随机对照试验 (RCT).
累积排名曲线下的面积 (SUCRA) 用于对干预的有效性进行排名.

主要成果:

重复的横磁性刺激 (rTMS) 在减少抑郁症状方面表现出最高的疗效 (HDRS: 89.0%).
甲爆刺激 (TBS) 显示了最高的响应率 (69.6%),rTMS也表现良好 (61.8%).
rTMS在认知结果方面也排名最高 (MMSE: 86.4%),右侧单侧电疗法 (RUL ECT) 的表现优于双边ECT (BL ECT).

结论:

NIBS,特别是rTMS和TBS,为患有MDD的老年人提供了有效的治疗选择.
这些方法也可能对这个患者群体的认知功能产生积极影响.
需要进行更大规模的随访试验来证实这些发现并指导临床应用.

关键词:

抑郁症抑郁症抑郁症网络元分析网络元分析非侵入性大脑刺激年龄较大的患者.

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