皮质醇和C反应蛋白 (CRP) 调节在严重的精神障碍中
Amina Inova1, Viktoria Birkenæs2, Daniel S Quintana3
1Institute of Clinical Medicine, University of Oslo, Norway.
Psychoneuroendocrinology
|December 31, 2024
概括
精神分裂症和双相情感障碍患者显示HPA轴免疫调节受损,由较低的皮质醇/CRP比率表明. 这种失调与精神药物治疗和身体质量有关,强调需要体重管理和一致的医疗护理.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 精神分裂症 (SZ) 和双相情感障碍 (BD) 与压力系统异常和炎症有关.
- 下垂体-垂体-上腺 (HPA) 轴与SZ和BD中的免疫调节之间的相互作用需要进一步研究.
研究的目的:
- 与健康对照组相比,研究SZ和BD患者的HPA轴免疫调节.
- 探索HPA轴免疫调节和SZ和BD中的临床/认知功能之间的关系.
主要方法:
- 从SZ (N=257),BD (N=153) 和健康对照 (N=40) 的血液样本中测量了皮质醇和C反应蛋白 (CRP).
- 计算了皮质醇/CRP比作为HPA轴免疫调节的标志物.
- 评估全球功能,症状严重程度和认知功能,使用标准化秤和测试.
主要成果:
- 患有SZ或BD的个体表现出比健康对照显著较低的皮质醇/CRP比率.
- 在调整身体质量指数 (BMI) 后,皮质醇/CRP比率的差异并不显著.
- 接受心理治疗的患者与未接受治疗的患者相比,皮质醇/CRP比率较低.
- 在SZ中,较低的皮质醇/CRP比率与较差的整体功能,症状严重程度增加和认知功能受损 (口头记忆,学习,处理速度) 相相关.
- 在BD组中,皮质醇/CRP比率和临床/认知功能之间没有发现显著的关联.
结论:
- 研究结果表明,在精神分裂症中存在HPA轴免疫失调.
- 在SZ和BD中破坏HPA轴免疫调节与精神药物治疗和身体脂肪质量有关.
- 临床管理应考虑体重控制和定期监测SZ和BD患者的精神药物治疗.
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