随机对照试验支持鼻炎指南的可靠性是多少?
Najm S Khan1, Aatin K Dhanda2, Masayoshi Takashima2
1Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA; Department of Otolaryngology - Head and Neck Surgery, Houston Methodist, Houston, TX, USA.
American journal of otolaryngology
|December 31, 2024
概括
支持鼻炎指南的随机对照试验显示强度低. 未来的研究应该报告脆弱性指数 (FI) 以将发现置于背景.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 临床试验方法论 临床试验方法论
背景情况:
- 关于过敏和鼻科的国际共识声明:鼻炎 (ICAR-RS) 指南依赖于随机对照试验 (RCT).
- 评估证据的可靠性对于准则的有效性至关重要.
研究的目的:
- 评估支持当前鼻炎指南 (ICAR-RS) 的RCT的稳定性.
主要方法:
- 分析了ICAR-RS中引用的RCT,主要结果是二分化的.
- 计算了统计学意义上的试验的脆弱性指数 (FI).
- 评估了试验特征,FI和失去了随访 (LTF) 的患者之间的关联.
主要成果:
- 38个RCT符合标准;31%评估了手术,24%是行业赞助的.
- 平均FI为2.5,其中67%的试验FI≤3,表明强度低.
- FI与行业支持无关;33%的试验具有FI ≤LTF.
结论:
- 支持ICAR-RS指南的RCT显示了整体的低稳定性.
- 建议未来的鼻炎试验报告FI,以改善结果的解释.
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