双边内部上喉神经注射,用于无法解释的慢性咳
Andrew Jay Bowen1, Ariel Roitman2, Sydney Ring1
1Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, United States of America.
American journal of otolaryngology
|December 31, 2024
概括
双边内部上喉神经 (iSLN) 注射为无法解释的慢性咳 (UCC) 提供安全有效的治疗方法. 这种方法可以减少有效的症状管理所需的访问次数.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 肺部病理学 肺部病理学
- 神经学 神经学
背景情况:
- 无法解释的慢性咳 (UCC) 是一种使人虚弱的疾病.
- 内部上喉神经 (iSLN) 注射类固醇和麻醉剂已经显示出UCC治疗的前景.
- 最初的协议涉及单边的iSLN注射.
研究的目的:
- 评估UCC同时进行双边iSLN注射的安全性.
- 评估双边iSLN注射后患者报告的结果.
- 探索影响治疗有效性的因素.
主要方法:
- 在2018年至2023年期间治疗的12名UCC患者的回顾性图表审查.
- 同时进行双边iSLN注射.
- 记录了患者报告的咳改善,并发症和反应持续时间.
- 统计分析检查了咳持续时间的影响,URI之前,先前的治疗,症状横向性和喉腔镜检查结果.
主要成果:
- 没有发生吸收事件;仅报告了3个轻微的自我限制并发症.
- 75%的患者报告说情况有所改善,平均响应率为73%,持续2.2个月.
- 异常的柔性喉镜/镜检查结果与较大的初始注射反应相关 (p ≤ 0.02).
结论:
- 同时的双边iSLN注射是UCC的安全有效治疗方式.
- 这种方法可能会减少所需的治疗次数.
- 研究结果表明,客观的喉发现可以预测治疗反应.
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