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预测和监测适应性辐射治疗时间使用基于二维X射线图像的水等效厚度的二维X射线图像

Kouta Hirotaki^1,2, Shunsuke Moriya³, Kento Tomizawa⁴

¹Doctoral Program in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.

Anticancer research

|December 31, 2024

概括

适应性得分 (AS) 有效地预测了在头癌中适应性辐射治疗 (ART) 的最佳时间. 基于二维X射线图像的水相当厚度 (2DWET) 显示了这种预测的潜力.

科学领域:

辐射瘤学辐射瘤学
医疗成像医学成像
癌症治疗方法癌症治疗方法

背景情况:

适应性辐射疗法 (ART) 需要精确的时间来获得最佳的患者结果.
预测ART时间传统上依赖于主观临床评估和重复成像.

研究的目的:

评估一种新型适应性得分 (AS) 的有效性,以预测最佳ART时间.
评估基于二维X射线图像的水相当厚度 (2DWET) 作为ART决策的预测因素.

主要方法:

在治疗期间,40名患有口/鼻癌的患者接受了CT扫描.
根据剂量指数的变化开发了一个自适应得分 (AS).
使用后勤回归和ROC分析来确定AS截止值和2DWET预测值.

主要成果:

AS与瘤学家的ART决定有很强的相关性 (r=0.74,0.64).
7.5的AS截止值准确地预测了ART需求 (灵敏度为79.2-89.5%,特异性为81.0-87.5%).
2DWET发现AS值为7.5,敏感度为63.2%,特异性为81.0%.

结论:

7.5的AS是ART时间的可靠指标,与专家瘤学家的判断一致.
2DWET提供了一种有希望的低暴露方法,用于预测头癌患者的ART时间.

关键词:

二维X射线图像的二维图像.适应性辐射疗法适应性辐射疗法头部和部癌症头部和部癌症监测解剖学变化的监测.这是ART的最佳时机.厚度相当于水的厚度.

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X-ray Imaging

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German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...