F-FDG-PET/CT衍生的瘤葡萄糖代谢活动,营养风险和软组织肉瘤患者的生存率之间的关系
Hiromichi Oshiro1, Kohei Mizuta1, Yuta Miyashi1
1Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Anticancer research
|December 31, 2024
概括
在18F-FDG-PET/CT上较高的最大标准化吸收值 (SUVmax) 和较低的老年营养风险指数 (GNRI) 表明软组织肉瘤患者的预后较差. 这表明瘤代谢升高会影响营养状况和生存结果.
科学领域:
- 在瘤学瘤学.
- 核医学就是核医学.
- 放射学 放射学是一门学科.
背景情况:
- 软组织瘤 (STSs) 是一种异质的恶性瘤群.
- 在STS中评估预后因素对于治疗规划和患者管理至关重要.
- 老年营养风险指数 (GNRI) 是评估老年人营养状况的有效工具.
研究的目的:
- 为了研究18F-氧葡萄糖正子发射断层扫描计算断层扫描 (18F-FDG-PET/CT) 测量的最大标准化吸收值 (SUVmax) 与STSs患者的老年营养风险指数 (GNRI) 之间的关系.
- 确定这些参数是否与STS患者的生存结果相关.
主要方法:
- 一项回顾性观察性研究包括81名STS患者,他们接受了18F-FDG-PET/CT.
- 在治疗前收集了血清白蛋白,身高和体重.
- 与GNRI和生存数据 (总生存率和无病生存率) 相比,分析了SUVmax值.
主要成果:
- 与较低SUVmax组 (<11.1) 相比,较高的SUVmax (≥11.1) 与较低的5年整体存活率 (79.7%) 和无病存活率 (52.4%) 相关.
- 与负风险组 (9.7±8.1) (p=0.03) 相比,正风险GNRI组的患者显示SUVmax显著更高 (19.1±14.9).
- 在SUVmax和GNRI之间观察到显著的负相关性 (r=-0.48,p<0.05).
结论:
- 升高的SUVmax和降低的GNRI是STS患者预后不佳的潜在指标.
- 瘤葡萄糖代谢的增加,反映在较高的SUVmax上,可能会对营养状况 (较低的GNRI) 和生存率产生负面影响.
- 这些发现凸显了18F-FDG-PET/CT和GNRI作为STS管理中的预后生物标志物的潜在作用.
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