改善的维生素D状况与较低的死产发生率有关
Pelle G Lindqvist1, Mika Gissler2,3,4
1Department of Clinical Sciences and Education, Karolinska Institute, Obstetrics and Gynecology, Södersjukhuset, Stockholm, Sweden; Pelle.lindqvist@ki.se.
Anticancer research
|December 31, 2024
概括
通过食品强化改善维生素D状况,在芬兰和瑞典显著降低了死产率. 这项大规模的研究表明,维生素D水平与怀孕结果之间存在明显的联系.
科学领域:
- 产科和妇科 产科和妇科
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 之前的研究表明,低血维生素D水平的妇女出生窒息的几率翻了一番,死产的风险增加了四倍.
- 目前尚不清楚这些不良妊娠结果是由于阳光照射减少或维生素D本身不足而导致的.
研究的目的:
- 调查维生素D状况与死产风险之间的因果关系.
- 评估国家维生素D食品强化计划对死产发病率的影响.
主要方法:
- 与芬兰和瑞典国家维生素D状况相关的死产发病率分析 (1994-2021,超过430万例怀孕).
- 检查芬兰维生素D食品强化计划 (2003年实施,2009年加强) 后死产率的变化.
- 使用95%置信区间进行交叉表格分析,以将维生素D状态的变化与死产率相关联.
主要成果:
- 芬兰出生死胎的发生率从2003年以前的4.1/1,000下降到2009年后的2.8/1,000,与强化相吻合.
- 瑞典的死胎率一直保持不变,直到2018年加强实施,之后从3.9/1,000下降到3.2/1,000
- 怀孕期间肝脏内胆固醇症的发生率,另一个与维生素D缺乏相关的疾病,并没有下降.
结论:
- 通过国家食品强化实现的维生素D状况的改善与死亡出生率的降低有关.
- 死亡出生率的减少表明与增强的维生素D水平存在剂量依赖的关系.
- 维生素D食品强化是一种有效的公共卫生策略,可以改善怀孕的结果.
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