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治疗慢性胸腔切除术后疼痛的斯凯坦胺疗效:系统审查和元分析的协议

Shu Juan¹, Xing Lu², Junhui Zhou³

¹Department of Anesthesiology, Xinyang Central Hospital, Xinyang, Henan, China.

|December 31, 2024

概括

这一系统性审查评估了对慢性胸切除术后疼痛 (CPTP) 的埃斯基坦胺. 它旨在确定胺是否有效减少疼痛并改善功能,同时评估其安全性.

科学领域:

麻醉学麻醉学
疼痛医学医学疼痛医学
药理学药理学是指药理学的学科.

背景情况:

胸切除术后的慢性疼痛 (CPTP) 是胸部手术后的一种衰弱性疾病.
目前的CPTP管理策略给临床医生带来了挑战.
埃斯凯特胺在治疗各种疼痛疾病,包括慢性疼痛方面表现有前途.

研究的目的:

系统地审查和元分析ESKETAMINE在治疗CPTP中的疗效.
评估埃斯基他明对疼痛强度和功能结果的影响.
评估阿片类药物消费和与ESKETAMINE相关的不良影响.

主要方法:

在多个数据库 (PubMed,Embase,Web of Science等) 进行全面的文献搜索. 在2024年4月之前.
包括随机对照试验,比较ESKETAMINE与安慰剂或成年人CPTP标准治疗.
主要结局包括3,6或12个月CPTP发病率;次要结局涉及疼痛得分,阿片类药物使用和不良事件.

主要成果:

数据提取和质量评估由两个独立研究人员.
对于符合条件的研究,将使用Review Manager V.5.3进行元分析.
该审查将量化ESKETAMINE在CPTP管理中的有效性和安全性.

结论:

这一系统性审查和元分析将提供基于证据的洞察力,了解胺在管理CPTP中的作用.
这些发现将为临床实践提供有关治疗胸切除术后疼痛时使用埃斯基坦胺的信息.
这项研究将有助于了解这种患者群体中石胺的益处和风险.

关键词:

慢性疼痛慢性疼痛慢性疼痛药物治疗药物治疗进行元分析分析.疼痛管理疼痛管理

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