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桃子成分特异性IgE测量有助于区分本地和全身反应在桃子过敏的日本患者
Yusuke Ando1, Sakura Sato2, Motohiro Ebisawa2
1Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan.
概括
对桃子过敏的组件解决诊断表明Pru p1与局部反应和Pru p7与全身反应有关. 测试这些特定免疫球蛋白E抗体 (sIgE ab) 组件有助于区分反应类型.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 食物过敏的诊断 食物过敏的诊断
- 临床医学 临床医学
背景情况:
- 组件解决诊断 (CRD) 对于准确的食物过敏诊断至关重要.
- 关于在多中心环境中桃子过敏原成分的敏感性概况的数据有限.
- 本研究评估了针对桃子过敏原成分的特定免疫球蛋白E抗体 (sIgE ab) 测试的临床实用性.
研究的目的:
- 评估各个桃子过敏原成分在区分局部反应 (LR) 和系统反应 (SR) 中的诊断价值.
- 调查与桃子过敏的不同临床表现相关的敏感化模式.
- 评估CRD在桃子过敏多中心环境中的实用性.
主要方法:
- 在四个中心注册了67名日本患者,他们确实对桃子过敏.
- 患者被分为局部反应 (LR) 和系统反应 (SR) 组.
- 血清特异性免疫球蛋白E抗体 (sIgE ab) 测试对桃子原料的过敏原和特定成分 (Pru p1,Pru p3,Pru p4,Pru p7) 以及树木花粉进行了测试.
主要成果:
- 对于LR,Pru p1显示了最高的诊断准确性 (曲线下的区域),其次是Pru p4.
- 试验p7显示了SR的最高诊断准确性.
- 显著比例的SR患者对桃子原料sIgE ab的检测是负的,但对Pru p 7sIgE ab的检测是阳性的.
结论:
- 对Pru p 1的敏感性与桃子过敏中的LR有关.
- 对Pru p 7的敏感性与SR密切相关.
- 测量Pru p1,Pru p4和Pru p7的sIgE位对于区分LR和SR在日本桃子过敏患者中具有临床价值.
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