在芬兰的SUPER研究中,精神疾病中的通用医学并发症
Johan Ahti1, Tuula Kieseppä2, Willehard Haaki3
1Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Schizophrenia (Heidelberg, Germany)
|December 31, 2024
概括
患有精神障碍的人,如精神分裂症,因一般医疗条件而面临过早死亡. 虽然肥胖和吸烟很常见,但它们不能完全解释精神分裂症患者患糖尿病和COPD等疾病的更高率.
科学领域:
- 精神病学和公共卫生
背景情况:
- 精神病障碍,包括精神分裂症 (SZ),精神分裂情绪障碍 (SZA),双相情感障碍 (BD) 和精神病抑郁症 (PD),与可预防的通用医学并发症 (GMCs) 的过早死亡率有关.
- 精神病,风险因素和GMC之间的相互作用是复杂的,需要进一步调查,特别是在SZA和PD.
研究的目的:
- 评估在芬兰国家大样本中基于登记册的精神病障碍和GMC诊断之间的关联.
- 检查身体质量指数 (BMI) 和吸烟是否解释精神病患者中GMC患病率的诊断差异.
主要方法:
- 在芬兰SUPER研究中对10,417名参与者的横截面研究.
- 用于精神病和GMC (高血压,糖尿病,COPD,癌症,缺血性心脏病,肝脏疾病) 的注册数据.
- 收集了参与者的BMI和吸烟状态的数据;使用后勤回归来分析总和直接的影响.
主要成果:
- 在所有诊断组中,肥胖的高患病率 (平均BMI 30.3 kg/m2) 和目前的吸烟率 (42.4%).
- 与其他精神病相比,精神分裂症 (SZ) 中糖尿病和COPD的发生率明显高.
- 仅仅肥胖和吸烟状态并不能解释诊断类别之间的GMC流行率观察到的差异.
结论:
- 肥胖和吸烟在所有精神疾病诊断类别中都非常普遍,需要持续的预防工作.
- 不同的精神疾病之间存在显著的GMC患病率差异,独立于肥胖和吸烟状态.
- 需要进一步的研究,以了解导致精神病患者GMC差异的复杂因素.
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