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Updated: May 7, 2025

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针对瘤细胞表面受体的蛋白质溶解向嵌合体 (PROTAC) 驱动的抗体内部化

Ezequiel J Tolosa1, Lin Yang1, Jennifer Ayers-Ringler1

  • 1Mayo Clinic, Rochester, MN, USA.

Communications biology
|December 31, 2024
PubMed
概括

蛋白质溶解向嵌合体 (PROTACs) 通过诱导强制细胞吸收来增强抗体-药物结合体 (ADC) 的内化和有效性. 这种组合策略显示出改善癌症治疗结果的希望.

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