异常的静止状态功能网络中心性和认知障碍在未经药物治疗的euthymic双极性患者中
Hong Li1, Qijin Wu1, Jiahui Wang1
1Department of Psychiatry, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
BMC psychiatry
|December 31, 2024
概括
双相情感障碍 (BD) 的认知障碍与前脑区域和脑岛的改变大脑连接有关. 这些神经网络的变化可能解释了即使在euthymic状态中也观察到的缺陷.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 认知障碍在双相情感障碍 (BD) 中很常见,影响生活质量.
- 在BD中认知缺陷的神经生物学基础仍然不清楚,即使是在euthymic时期.
研究的目的:
- 为了研究无药的脑连接异常,euthymic个体与BD.
- 探索大脑活动变化与认知功能之间的关联.
主要方法:
- 使用了度中心性 (DC) 分析和基于DC (种子) 的功能连接 (FC).
- 参与者有34名BD患者和35名健康对照 (HC) 患者.
主要成果:
- 与HC患者相比,BD患者在额头区域 (例如,中间额头,下额头) 和左侧胰岛发生了改变的DC.
- 在特定大脑区域的DC值和认知评估得分之间发现了相关性.
- 在BD患者中发现了默认模式网络 (DMN),前额对等网络 (FPN) 和中央执行网络 (CEN) 的变化.
结论:
- 涉及额头区域和丘脑的异常神经网络可能是euthymic BD中认知缺陷的基础.
- 这些发现表明,在稳定的情绪状态下,在BD中理解认知障碍的潜在神经标志物.
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