整合多层次的生物先验来提高牛肉牛的基因组预测准确度
Zhida Zhao1, Qunhao Niu1, Jiayuan Wu1
1Key Laboratory of Animal Genetics Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Biology direct
|December 31, 2024
概括
整合多omics数据可以提高肉牛的基因组预测准确度. 进化和功能变异显著提高复杂特征的预测,增强遗传洞察力.
科学领域:
- 动物基因组学 动物基因组学
- 量化遗传学 量化遗传学
- 生物信息学是一种生物信息学.
背景情况:
- 复杂特征的基因组预测 (GP) 可以通过整合多层信息来改进.
- 使用多omics数据的GP有效策略仍在开发中.
研究的目的:
- 评估功能变异从多组数据对肉牛基因组预测的贡献.
- 提高基因组预测对经济重要特征的准确性.
主要方法:
- 从基因组学,转录组学,代谢组学和表观遗传学数据生成了11个特征集.
- 使用GREML和排名变体得分评估变体贡献.
- 使用GBLUP和贝叶斯B模型对顶部变量集的预测准确度进行比较.
- 注释GWAS变体并进行了丰富分析.
主要成果:
- 观察到32个功能类别的显著丰富.
- 进化相关的集合 (保存,选择特征) 显示出高遗传性丰富.
- 顶级特征集变体显著提高了预测准确性 (11.6%贝叶斯B,7.54%GBLUP).
- 使用BayesB.使用脏重量的最大准确度增加 (31.52%)
结论:
- 整合多层次的生物信息可以提高对复杂特征遗传结构的理解.
- 多omics数据集成提高了牛肉牛的基因组预测准确度.
相关概念视频
The Central Dogma
19.3K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
19.3K
Genomics
35.2K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.2K
Evolutionary Relationships through Genome Comparisons
5.6K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.6K
Plant Breeding and Biotechnology
18.5K
Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.
18.5K
Human Genetics
469
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
469
Incomplete Dominance
20.2K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
20.2K


