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更多关于MDMA和MDMA辅助疗法

Aaron S Wolfgang1, Gregory A Fonzo1, Joshua C Gray1

  • 1Directorate of Behavioral Health, Walter Reed National Military Medical Center, Bethesda, MD (Wolfgang); Departments of Psychiatry (Wolfgang) and Medical and Clinical Psychology (Gray), Uniformed Services University, Bethesda, MD; Departments of Psychiatry (Wolfgang, Krystal), Neuroscience (Krystal), and Psychology (Krystal), Yale University School of Medicine, New Haven, CT; Center for Psychedelic Research and Therapy, Department of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School (Fonzo, Nemeroff); Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, UCLA (Grzenda); Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham (Kraguljac); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, Stanford University and Veterans Affairs Palo Alto Health Care System, Palo Alto, CA (Rodriguez).

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PubMed
概括

在治疗创伤后应激障碍 (PTSD) 方面,MDMA辅助疗法 (MDMA-AT) 是有前途的. 临床试验表明MDMA-AT是安全和有效的,与安慰剂相比,症状显著减少.

关键词:
临床药物研究 临床药物研究抑郁症 抑郁症 抑郁症 抑郁症这是MDMA,MDMA.严重的抑郁症 严重的抑郁症创伤后应激障碍 (PTSD) 是一种

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科学领域:

  • 神经科学是一个神经科学.
  • 精神病学是一个精神病学.
  • 药理学 药理学是指药理学的学科.

背景情况:

  • MDMA (3,4-methylenedioxymethamphetamine) 在娱乐和治疗上有历史性的使用.
  • 美国食品和药物管理局在2017年将MDMA辅助疗法 (MDMA-AT) 指定为PTSD的突破性疗法.
  • 娱乐性MDMA使用带有风险,由于 adulterants 和缺乏临床监督,限制外推到治疗环境.

研究的目的:

  • 为了区分娱乐性MDMA使用与受控MDMA-AT的证据.
  • 审查MDMA治疗效果背后的神经生物学机制.
  • 提出临床证据,公共卫生方面的考虑,以及MDMA-AT.未来的研究方向.

主要方法:

  • 关于在临床和非临床环境中使用MDMA的现有文献的审查.
  • 对PTSD中MDMA辅助治疗的临床试验数据的分析.
  • 检查与MDMA有关的神经生物学和药理学数据.

主要成果:

  • MDMA独特地促进了亲社会效应,信任和自我同情,同时保持了认知清晰度.
  • 在受控环境中,MDMA-AT证明了PTSD的安全性和有效性.
  • 在治疗后,67%-71%的创伤后应激障碍患者在使用MDMA-AT后不再符合诊断标准,而安慰剂患者的比例为32%-48%.

结论:

  • MDMA辅助疗法是一种潜在的突破性的PTSD治疗方法,与娱乐用途不同.
  • 药品级MDMA与心理治疗的控制临床管理显示了持久的积极结果.
  • 需要进一步的研究和政策考虑,以优化MDMA-AT的公共卫生影响.