儿童中COVID-19和正态不耐症之间的关联:一项回顾性研究
Bahram Kakavand1, Safia Centner2, Aliya Centner2
1Pediatric Cardiology, Nemours Children's Health System, Orlando, USA.
Cureus
|January 1, 2025
概括
后COVID-19感染或接种疫苗可能会导致儿童持续的静态不耐受 (OI) 和POTS. 这项研究在儿科患者中发现了POTS和自主功能障碍,强调了需要提高认识和研究的需要.
科学领域:
- 儿科自主神经学 儿科自主神经学
- 传染病免疫学 传染病免疫学
- 心脏病学 心脏病学
背景情况:
- 在COVID-19感染和接种疫苗后,如静态不耐受 (OI) 和POTS等持续症状越来越多地被报告.
- 姿势静止性心动节拍综合征 (POTS) 显著损害生活质量,由于过度心动节拍和其他症状站立时.
- 在SARS-CoV-2之后的自主功能障碍在儿科患者中越来越令人担忧.
研究的目的:
- 评估COVID-19感染或接种疫苗后患有OI和POTS的儿科患者的临床和实验室发现.
- 在这个群体中使用标准化测试来评估自主功能.
- 调查COVID-19后POTS和相关自主性异常的流行情况.
主要方法:
- 在COVID-19后患有慢性头或昏迷的儿科患者 (18岁以下) 的回顾性图表审查.
- 自主功能测试包括倾斜表,瓦萨尔瓦机动,深呼吸测试和QSART.
- 分析临床症状,自主测试结果和汗水产量.
主要成果:
- 研究了16名儿科患者 (平均年龄15岁);14名感染后,2名接种疫苗后.
- 10名患者 (62.5%) 符合POTS标准,在倾斜表上平均每分钟心率增加49次.
- 在QSART (50%) 观察到异常的Valsalva (43.75%) 和小纤维神经病变;注意到高水平的北上腺素.
结论:
- COVID-19感染和接种疫苗与儿童的POTS和OI有关.
- 这些发现支持SARS-CoV-2和儿科自主功能障碍之间的联系.
- 进一步研究长期COVID对儿童的长期自主影响至关重要.
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