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美国怀孕期间抗偏头痛药物的安全性

A Bérard^1,2,3, S Strom⁴, D Albrecht⁴

¹Faculty of Pharmacy, University of Montreal, Montreal, Canada.

Frontiers in pharmacology

|January 1, 2025

概括

这项研究发现,在怀孕期间使用二醇胺 (DHE) 或三胺与早产或重大先天性形等不良结果之间没有显著的联系. 需要进一步的研究来证实关于隔膜缺陷的发现.

科学领域:

产科和妇科产科和妇科
药理学药理学是指药理学的学科.
公共卫生公共卫生

背景情况:

像DHE和triptans这样的抗偏头痛药物已被单独与不良妊娠结果联系起来.
关于与这些药物的妊娠使用相关的风险的最终共识尚不存在.

研究的目的:

为了量化早产,低出生体重 (LBW),重大先天性形 (MCM) 和妊娠DHE或三药使用的自发流产 (SA) 的风险.
分析这些风险在一个大型的,私人保险的美国队列.

主要方法:

使用美国Merative MarketScan研究数据库 (2011-2021) 进行的一项回顾性队列研究.
四个分析评估了早产,LBW,MCM和SA的风险.
用通用估计方程 (GEE) 控制混因素,包括母亲的偏头痛.

主要成果:

在一个767,994例怀孕的队列中,分析了DHE (0.02%) 和三 (0.56%) 的使用情况.
无论是DHE还是triptan的使用都没有统计学上显著地与早产,LBW,MCM或SA的风险增加有关.
DHE的使用显示出与隔膜缺陷的潜在关联,但这些发现是不稳定的,需要复制.

结论:

孕期暴露于DHE (头三个月) 和药与早产,LBW,MCM或SA的风险增加没有显著关联.
观察到的DHE和隔膜缺陷之间的关联可能是由于偶然而引起的,需要进一步调查.

关键词:

美国美国美国出生时体重较低的婴儿.主要的先天性形主要的先天性形.药物药物药物药物偏头痛偏头痛偏头痛偏头痛怀孕怀孕怀孕怀孕怀孕时间过早的早产.这是自发流产.

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