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疾病肥胖症的抗凝血方法:关于静脉血栓塞栓症管理的综合性审查
Victorita Sorodoc1,2, Andreea Asaftei1, Alexandr Ceasovschih1,2
12nd Internal Medicine Department, Sf. Spiridon Clinical Emergency Hospital, Iasi, Romania.
Frontiers in pharmacology
|January 1, 2025
概括
在患有病态肥胖症的患者中,管理静脉血栓塞栓症 (VTE) 需要仔细考虑抗凝剂剂量. 证据有限,需要量身定制的方法和密切监测,以在这个人群中获得最佳的VTE治疗.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肥胖是静脉血栓塞栓症 (VTE) 的重要危险因素.
- 在患有病态肥胖症的患者中管理抗凝血药物具有独特的药理动力学和药理动力学挑战.
- 对于极度体重 (BMI ≥40 kg/m2或体重≥120 kg) 的个体,抗凝剂的疗效和安全性的证据有限.
研究的目的:
- 为提供对病态肥胖患者VTE抗凝治疗的综合性审查.
- 综合当前的证据和建议,以预防和治疗这一群体的抗凝药.
- 分析极端体重对抗凝血药物的影响.
主要方法:
- 对用于静脉瘤治疗的抗凝血剂的研究进行系统审查.
- 对维生素K对抗剂 (VKA),未分离氨酸 (UFH),低分子量氨酸 (LMWH),芬达巴鲁努克斯和直接口服抗凝剂 (DOAC) 的数据分析.
- 探索特殊的子群体,包括那些患有癌症,功能障碍或腹腔外科手术后的人.
主要成果:
- 目前对患有VTE的致病性肥胖患者的抗凝药治疗的证据不足.
- 在不同的抗凝血剂类别中观察到不同的疗效和安全性.
- 对于具有并发性疾病的子群体,需要特别考虑.
结论:
- 量身定制的方法和仔细的监测对于在患有VTE的病态肥胖患者中有效的抗凝药至关重要.
- 需要进一步的研究,以建立最佳的抗凝剂策略,为这一群体.
- 为了达到最佳的治疗平衡,需要个性化治疗计划.
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