患者和医生对晚期HCC疾病和治疗的期望:前性PERCEPTION1研究
Jean-Charles Nault1,2, Nanthara Sritharan3, Gontran Verset4
1Liver unit, Avicenne hospital, APHP Bobigny, France.
JHEP reports : innovation in hepatology
|January 1, 2025
概括
患者和医生对晚期肝细胞癌 (HCC) 治疗和预后的期望显著不同. 改善患者与医生的沟通对于更好地了解和管理晚期肝癌至关重要.
科学领域:
- 肝胆瘤学 肝胆瘤学
- 临床试验研究 临床试验研究
- 患者与医生的沟通 患者与医生的沟通
背景情况:
- 接受全身治疗的晚期肝细胞癌 (HCC) 患者与医生的评估相比,预期不同.
- 了解这些差异是改善晚期肝癌患者护理和治疗坚持的关键.
研究的目的:
- 将患者的期望与医生对高级HCC治疗和预后的评估进行比较.
- 确定影响患者与医生的一致性和患者心理状态 (焦虑/抑郁) 的因素.
主要方法:
- 在法国和比利时接受全身治疗的205名晚期HCC患者 (BCLC B/C阶段) 的前性研究.
- 患者完成了期望调查和医院焦虑和抑郁量表 (HADS);医生完成了单独的调查.
- 分析包括一致性,HADS和生存预测准确性的单变量和多变量模型.
主要成果:
- 在预期寿命方面观察到显著差异,患者比医生更乐观.
- 较低的患者-医生一致性与较短的咨询,女性医生,BCLC C阶段和高的医生病例量有关.
- 52%的患者经历过焦虑/抑郁,与α-fetoprotein水平相关;医生预测的存活期 (18个月) 与观察到的存活期 (13个月) 有微弱的相关性.
结论:
- 患者和医生对先进的HCC治疗和预后的期望显示出显著的差异,因国家而异.
- 这些差异凸显了加强患者理解和促进改善患者与医生的沟通的干预措施的必要性.
- 解决心理困扰和调整期望对于管理晚期肝细胞癌至关重要.
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