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在被切除的脊柱植入物上鉴定低致病性细菌,以及对抗微生物预防的含义
Ann-Kathrin Joerger1, Vicki M Butenschoen1, Susanne Feihl2
1Department of Neurosurgery, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
Brain & spine
|January 1, 2025
概括
像Cutibacterium acnes和Staphylococcus epidermidis这样的低致病性细菌在脊柱植入物上很常见. 目前的抗生素预防可能不完全有效,尤其是对 Staphylococcus epidermidis 的预防,需要对抗菌战略进行审查.
科学领域:
- 脊柱外科手术 脊柱外科手术
- 传染性疾病传染性疾病.
- 微生物学 微生物学
背景情况:
- 在被切除的脊柱植入物上,低致病性细菌的作用尚不清楚.
- 目前对这些细菌进行的外科手术期间抗生素预防的有效性尚未得到充分研究.
研究的目的:
- 为了研究脚螺丝松动和特定病原体之间的关联.
- 评估术后抗生素在预防脊柱植入物上的细菌定居的疗效.
主要方法:
- 93名脊柱植入物切除患者的回顾性分析 (2018年1月1日 - 2020年3月31日).
- 包括放松和不放松的植入物,但不包括急性感染和特定的植入物材料.
- 细菌培养和抗生素耐药性对预防性抗生素的分析.
主要成果:
- 在41%的放松植入物和27%的不放松植入物中发现了细菌分离物.
- 昆虫细菌 (敏感) 和表皮球菌 (耐药) 是最常见的分离物.
- 总体而言,抗生素敏感度为75%,对Staphylococcus epidermidis.观察到完全的耐药性.
结论:
- 由于敏感的Cutibacterium acnes和耐药的Staphylococcus epidermidis的高发病率,目前的抗菌预防需要重新评估.
- 需要进一步的研究来澄清脊柱植入物,特别是未松动的脊柱植入物上低毒性细菌的临床意义.
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