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训练有素的先天免疫力是预先怀孕症和未来心血管疾病之间的潜在联系

Ivo Carrasco-Wong¹, Javiera M Sanchez¹, Jaime A Gutierrez¹

¹Escuela de Tecnología Médica, Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile.

Frontiers in endocrinology

|January 1, 2025

概括

孕前 (PE) 可能通过训练天生的免疫力 (TRIM) 导致长期心血管疾病. 当暴露于与损伤相关的分子模式 (DAMPs) 时,这种情况就会发生,在表观遗传上重新编程免疫细胞,增加炎症和未来心血管风险.

科学领域:

免疫学免疫学免疫学
心血管科学心血管科学
生殖医学生殖医学

背景情况:

孕前 (PE) 影响2-6%的怀孕,导致高血压和潜在的蛋白尿.
乳腺发育涉及与损伤相关的分子模式 (DAMP),诱导母亲的炎症和内皮功能障碍.
虽然已知即时风险,但PE与长期孕产妇心血管疾病的联系尚不清楚.

研究的目的:

探索受过训练的先天性免疫 (TRIM) 作为先兆子和长期心血管风险之间的机制性联系.
研究PE期间的DAMPs如何在表观遗传上重编程先天免疫细胞.

主要方法:

关于PE,DAMP,先天免疫和心血管疾病的现有文献的审查.
假设表观遗传重编程和TRIM在PE长期影响中的作用.

主要成果:

在PE中持续暴露于DAMP可能会在表观遗传上重编程先天免疫细胞,诱导TRIM.
这种TRIM可以增强炎症反应,导致慢性炎症和内皮功能障碍.
TRIM可能会使女性在晚年更容易患心血管疾病.

结论:

训练有素的先天免疫 (TRIM) 是一种潜在的机制,可以将先兆子 (PE) 与长期心血管风险的增加联系起来.
了解TRIM的作用为PE病理生理学和潜在的治疗点提供了洞察力.
对先天免疫细胞表观遗传和代谢变化的进一步研究至关重要.

关键词:

DAMP (损伤相关的分子模式分子)长期持续的影响.孕产妇的心血管健康孕前症是什么意思训练有素的免疫力

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