小肠细菌过度生长和与代谢功能障碍相关的脂肪性肝病
Ziteng Wang1,2, Wentao Tan1, Jiali Huang1
1Department of Gastroenterology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Frontiers in nutrition
|January 1, 2025
概括
小肠细菌过度生长 (SIBO) 与代谢功能障碍相关的脂肪性肝病 (MASLD) 密切相关. 这次审查发现SIBO增加了MASLD的发展和进展,特别是在更严重的肝病中.
科学领域:
- 胃肠病学和肝病学
- 微生物学 微生物学
- 代谢疾病 代谢疾病
背景情况:
- 小肠细菌过度生长 (SIBO) 涉及改变的肠道微生物群,影响消化和吸收.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 显示了肠道微生物群和代谢概况的显著变化.
- 新出现的证据表明,SIBO和MASLD病原体之间存在联系.
研究的目的:
- 系统地审查和综合关于SIBO和MASLD之间关联的数据.
- 探索SIBO如何为MASLD的发展和进展做出贡献.
主要方法:
- 在主要数据库 (Embase,PubMed,科学网,奥维德,科克兰) 进行全面的文献搜索.
- 包括横截面,队列和病例控制研究,使用纽卡斯尔-太华尺度进行质量评估.
- 使用奇平方测试,几率比率 (OR),置信区间 (CI) 和随机效应模型进行异质性的元分析.
主要成果:
- 在SIBO和MASLD之间发现了显著的关联 (OR = 3.09).
- 随着MASLD的严重程度,SIBO阳性增加,肝脏活检确认的MASLD的ORs更高 (OR = 4.89).
- 对肠道透性测试的亚组分析显示出一个显著的关联 (OR = 3.86). 超回归表明种族和发展水平影响了协会.
结论:
- SIBO与MASLD有着密切的联系,可能有助于其发展和进步.
- 观察到最强的联系与特定的诊断方法:乳糖呼吸测试,肠道微生物群培养,肝活检和肠道透性测试.
- 种族和地区发展水平是影响SIBO-MASLD关系的关键因素.
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