CD19 CAR-T细胞疗法:对自身免疫性风湿性疾病的新黎明?
Carlos Rangel-Peláez1, Laura Martínez-Gutiérrez1, María Tristán-Manzano2
1Institute of Parasitology and Biomedicine López-Neyra, Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain.
Frontiers in immunology
|January 1, 2025
概括
化学抗原受体 (CAR) -T细胞疗法,特别针对CD19,通过耗尽自身反应性B细胞,对自身免疫性风湿性疾病 (ARDs) 显示出希望. 需要进一步的研究来优化其用于安全有效的自身免疫治疗.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 细胞疗法细胞疗法
背景情况:
- 自身免疫性类风湿性疾病 (ARDs) 涉及慢性炎症和由于免疫反应失调而导致的组织损伤.
- 目前用于ARD的治疗方法通常有效性有限,特别是在持久自动反应性B细胞患者中.
研究的目的:
- 审查CD19化学抗原受体 (CAR) -T细胞治疗在治疗自身免疫性类风湿性疾病 (ARDs) 的潜力.
- 突出临床成果,并讨论在自身免疫治疗中采用CAR-T细胞治疗的关键考虑因素.
主要方法:
- 对CAR-T细胞治疗现有文献的综述,重点关注CD19 CAR-T细胞.
- 对应用CAR-T细胞治疗ARDs的临床成果和挑战的分析.
主要成果:
- CD19 CAR-T 细胞已经成功地证明了消耗B细胞的成功,这是ARDs的关键因素.
- 早期的临床数据表明,ARDs可能有缓解的潜力.
结论:
- CD19 CAR-T细胞疗法通过向自身反应性B细胞来治疗ARD具有显著的前景.
- 进一步的研究对于解决最佳目标细胞种群,CAR结构设计,毒性和免疫重置对于安全有效的临床应用至关重要.
关键词:
CD19 卡特-T 的自免疫性类风湿性疾病.类风湿性关节炎 类风湿性关节炎系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.系统性硬化症 系统性硬化症更多相关视频
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)
相关概念视频
01:27Tumor Immunotherapy
472
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
472
01:29Autoimmune Disorders
385
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
385
01:24T Cell Types and Functions
946
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
946
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
114
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
114