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土壤类型对细菌生长的影响以及对实验添加的人类抗生素的耐受性

Laura Rodríguez-González¹, Montserrat Díaz-Raviña², Beatriz Sevilla-Morán³

¹Área de Edafoloxía e Química Agrícola, Departamento de Bioloxía Vexetal e Ciencia do Solo, Facultade de Ciencias, Universidade de Vigo, Campus As Lagoas, s/n, Ourense 32004, Spain; Instituto de Agroecoloxía e Alimentación (IAA). Universidade de Vigo, Campus Auga, Ourense 32004, Spain.

Ecotoxicology and environmental safety

|January 1, 2025

概括

当废水用于灌时,常见的抗生素sefuroxime (CXM) 和azithromycin (AZI) 对土壤细菌构成威胁. 这项研究量化了它们的毒性,并发现抗生素的压力可以导致土壤细菌产生耐受性.

科学领域:

环境科学环境科学
微生物学微生物学
土壤科学土壤科学

背景情况:

通常处方的抗生素,素 (CXM) 和亚齐素 (AZI),被检测到污水排水中.
使用这些废水灌将抗生素引入农业土壤,可能损害土壤微生物群.
关于CXM和AZI对土壤的毒性和生态影响的研究有限.

研究的目的:

在不同类型的土壤中量化CXM和AZI的毒性.
随着时间的推移,追踪抗生素毒性的演变和对土壤细菌群体的影响.
在选择性压力下研究土壤细菌对抗生素耐受性的发展.

主要方法:

12种不同的作物土壤暴露于CXM和AZI的不同度.
使用Log IC50值 (抑制50%细菌生长的抗生素度对数) 测量抗生素毒性.
在42天的时间内监测细菌生长抑制和耐受性发展.

主要成果:

CXM和AZI都对土壤细菌表现出毒性,CXM最初比AZI更有毒.
在某些土壤中,AZI在42天之前表现出持续的毒性,而CXM的影响随着时间的推移而减弱.
抗生素暴露,即使在低度,诱导土壤细菌的耐受性,耐受性水平因土壤类型而异.

结论:

CXM和AZI对土壤细菌群落和生态系统服务构成风险.
抗生素耐受性在土壤中的发展受到抗生素类型,度和土壤特征的影响.
需要进一步的研究来评估抗生素对土壤微生物群和人类健康的风险.

关键词:

亚齐思罗密辛是一种亚齐思罗密辛.塞福洛克西姆是一种素.氨酸的结合氨酸的结合污染的土壤污染的土壤污染引起的社区容忍度

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