自闭症诊断率与青少年抑郁症之间的关联:瑞典的一项基于人口的研究
Adrian E Desai Boström1, Peter Andersson2, Lee E Wachtel3
1Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Health Care Services, Karolinska University Hospital, Region Stockholm, Stockholm SE-171 76, Sweden; Department of Clinical Sciences/Psychiatry, Umeå University, Sweden; Stockholm Health Care Services, Region Stockholm, Sweden.
Psychiatry research
|January 1, 2025
概括
较高的自闭症谱系障碍率与较低的青少年抑郁症诊断相关. 这种反向关系在瑞典各地区的所有性别中都被观察到,这表明需要对这些关联进行进一步的研究.
科学领域:
- 儿童和青少年精神病学
- 神经发育障碍 神经发育障碍
- 精神卫生流行病学 精神卫生流行病学
背景情况:
- 在瑞典,自闭症谱系障碍 (ASD-R) 诊断率正在增加.
- 青少年中ASD-R和主要抑郁障碍 (MDD) 之间的关系尚不清楚.
- 这项研究探讨了瑞典青少年ASD-R和MDD诊断率之间的关联.
研究的目的:
- 调查青少年中自闭症谱系障碍 (ASD-R) 和严重抑郁症 (MDD) 诊断率之间的关联.
- 分析瑞典不同性别之间的这种关联.
- 确定可能存在的相关性,需要进一步调查.
主要方法:
- 使用瑞典注册数据的观察性研究 (2008-2022年).
- 通用线性混合模型 (GLMM) 分析15-19岁儿童的ASD-R (ICD-10:F84) 和MDD (ICD-10:F32) 初级诊断率.
- 模型根据精神病护理关联率,双相情感障碍率和性别比率进行调整,对男女,男性和女性进行单独分析.
主要成果:
- 在所有性别群体中,ASD-R和MDD诊断率之间发现了显著的反向关系.
- 在男女组合中,ASD-R与MDD诊断的平均比率为0.40 (P = 0.003).
- 性别特定的模型显示男性的比率为0.28 (P < 0.001) 和女性的比率为0.37 (P = 0.017),所有比率都明显低于1.
结论:
- 较高的ASD-R初级诊断率与青少年初级MDD诊断率较低有关.
- 这种反向相关性在男性中比女性更明显.
- 建议使用纵向,与共诊断的个性化数据进行进一步的研究,以了解这种关系.
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