在诊断结核性肺溢液时,介质素-27的准确性:应考虑年龄
Hong-Zhe Zhu1, Yan Niu2, Jian-Xun Wen2
1Department of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China; Department of Parasitology, the Basic Medical Sciences College of Inner Mongolia Medical University, Hohhot 010107, China; Key Laboratory for Biomarkers, Inner Mongolia Medical University, Hohhot 010050, China.
Cytokine
|January 1, 2025
概括
胸腔内白素-27 (IL-27) 显示出结核性胸腔溢出 (TPE) 的诊断潜力. 然而,它的准确性受患者年龄的影响,在年轻的队列中观察到最佳表现.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 生物标志物研究 生物标志物研究
背景情况:
- 结核性流 (TPE) 的诊断仍然具有挑战性.
- 之前的研究表明,多发性白内素-27 (IL-27) 可能有助于TPE诊断,但研究结果缺乏一致性.
研究的目的:
- 为了评估多IL-27对TPE的诊断准确性.
- 评估年龄对IL-27在TPE的诊断性能的影响.
主要方法:
- 预计将招募211名未被诊断的肺部溢血患者.
- 通过Mtb培养,染色,活检和治疗反应确认TPE.
- 通过ELISA测量腹IL-27水平;使用ROC曲线分析评估诊断准确性.
主要成果:
- 在TPE患者 (33) 中,IL-27的平均水平明显高于非TPE患者 (178).
- 总体IL-27的AUC为0.76;灵敏度为0.26,特异性为0.91在500ppg/ml时.
- 诊断准确度 (AUC) 提高到0.84,最高年龄为70岁,降至0.76在75岁时.
结论:
- 腹腔IL-27证明了TPE的诊断实用性.
- 年龄在TPE病例中显著影响IL-27的诊断性能.
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