在便和尿液样本中SAT-TB的诊断值用于肠道和尿道结核病
Zhao Wei1, Muhammad Tahir Khan2, Feng Zhiyu3
1Graduate School, Guangzhou Medical University, Guangzhou 511436, PR China.
Diagnostic microbiology and infectious disease
|January 1, 2025
概括
同时增强/结核病检测 (SAT-TB) 显示出在便样本中检测肠结核病的高诊断效率. 虽然对便有效,但其在尿样中的表现需要进一步调查结核病诊断.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 诊断发展 诊断发展
背景情况:
- 结核病的同时放大/测试 (SAT-TB) 是一种实时分子方法,针对16srRNA检测Mycobacterium tuberculosis.
- 精确诊断肠道和尿路结核病仍然是一个临床挑战,需要改进的诊断工具.
研究的目的:
- 这项研究旨在评估SAT-TB对肠道和尿路结核病的诊断性能.
- 该评估使用了从怀疑患有肠道或尿道结核病的患者的便和尿液样本.
主要方法:
- 从2021年到2022年,共收集了94个便和69个尿液样本.
- 使用SAT-TB,Xpert MTB/RIF试验和MGIT960培养物进行了结核菌菌的检测,以进行比较分析.
主要成果:
- 对于便样本,SAT-TB显示了53.33%的灵敏度和93.88%的特异性 (AUC:0.736).
- 对于尿样,SAT-TB显示灵敏度为27.27%和特异性为98.28% (AUC:0.628).
- 对比分析显示,在测试的方法中,SAT-TB对便样本的诊断效率最高.
结论:
- 在分析便样本时,SAT-TB显示出对肠结核的有希望的诊断效果.
- 使用尿样检测尿结核病的SAT-TB的诊断性能,与便样本相比,较低.
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